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A primer on molecular biology


Book Chapter


Modern molecular biology provides a rich source of challenging machine learning problems. This tutorial chapter aims to provide the necessary biological background knowledge required to communicate with biologists and to understand and properly formalize a number of most interesting problems in this application domain. The largest part of the chapter (its first section) is devoted to the cell as the basic unit of life. Four aspects of cells are reviewed in sequence: (1) the molecules that cells make use of (above all, proteins, RNA, and DNA); (2) the spatial organization of cells (``compartmentalization''); (3) the way cells produce proteins (``protein expression''); and (4) cellular communication and evolution (of cells and organisms). In the second section, an overview is provided of the most frequent measurement technologies, data types, and data sources. Finally, important open problems in the analysis of these data (bioinformatics challenges) are briefly outlined.

Author(s): Zien, A.
Pages: 3-34
Year: 2004
Day: 0
Editors: Schoelkopf, B., K. Tsuda and J. P. Vert
Publisher: MIT Press

Department(s): Empirical Inference
Bibtex Type: Book Chapter (inbook)

Address: Cambridge, MA, USA
Digital: 0
ISBN: ISBN 0-262-19509-7
Organization: Max-Planck-Gesellschaft
School: Biologische Kybernetik

Links: PDF


  title = {A primer on molecular biology},
  author = {Zien, A.},
  pages = {3-34},
  editors = {Schoelkopf, B., K. Tsuda and J. P. Vert},
  publisher = {MIT Press},
  organization = {Max-Planck-Gesellschaft},
  school = {Biologische Kybernetik},
  address = {Cambridge, MA, USA},
  year = {2004}