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Phenotypic characterization of chondrosarcoma-derived cell lines




Gene expression profiling of three chondrosarcoma derived cell lines (AD, SM, 105KC) showed an increased proliferative activity and a reduced expression of chondrocytic-typical matrix products compared to primary chondrocytes. The incapability to maintain an adequate matrix synthesis as well as a notable proliferative activity at the same time is comparable to neoplastic chondrosarcoma cells in vivo which cease largely cartilage matrix formation as soon as their proliferative activity increases. Thus, the investigated cell lines are of limited value as substitute of primary chondrocytes but might have a much higher potential to investigate the behavior of neoplastic chondrocytes, i.e. chondrosarcoma biology.

Author(s): Schorle, C. and Finger, F. and Zien, A. and Block, J. and Gebhard, P. and Aigner, T.
Journal: Cancer Letters
Volume: 226
Number (issue): 2
Pages: 143-154
Year: 2005
Month: August
Day: 26

Department(s): Empirical Inference
Bibtex Type: Article (article)

Digital: 0
Language: en
Organization: Max-Planck-Gesellschaft
School: Biologische Kybernetik

Links: Web


  title = {Phenotypic characterization of chondrosarcoma-derived cell lines},
  author = {Schorle, C. and Finger, F. and Zien, A. and Block, J. and Gebhard, P. and Aigner, T.},
  journal = {Cancer Letters},
  volume = {226},
  number = {2},
  pages = {143-154},
  organization = {Max-Planck-Gesellschaft},
  school = {Biologische Kybernetik},
  month = aug,
  year = {2005},
  month_numeric = {8}